After studying the 15 matchups on the Week 7 schedule in the NFL, our best against-the-spread suggestion is Chiefs +1.5. For more suggestions, which could lead to parlay opportunities, see below.

NFL Picks Against the Spread – Week 7

Jump to Matchup:

Pick: Chiefs +1.5 vs. 49ers

• Matchup: Kansas City Chiefs at San Francisco 49ers
• Projected Winner & Margin: Chiefs by 7.6 points (Bet on this game at BetMGM)
• Spread: 49ers -1.5
• Time: 4:25 p.m. ET
• Date: Oct. 20
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers +1.5 vs. Jets

• Matchup: New York Jets at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 10.1 points (Bet on this game at BetMGM)
• Spread: Jets -1.5
• Time: 8:20 p.m. ET
• Date: Oct. 20
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Saints +2.5 vs. Broncos

• Matchup: Denver Broncos at New Orleans Saints
• Projected Winner & Margin: Saints by 0.2 points (Bet on this game at BetMGM)
• Spread: Broncos -2.5
• Time: 8:15 p.m. ET
• Date: Oct. 17
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -2.5 vs. Lions

• Matchup: Detroit Lions at Minnesota Vikings
• Projected Winner & Margin: Vikings by 10.8 points (Bet on this game at BetMGM)
• Spread: Vikings -2.5
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -2.5 vs. Texans

• Matchup: Houston Texans at Green Bay Packers
• Projected Winner & Margin: Packers by 6.7 points (Bet on this game at BetMGM)
• Spread: Packers -2.5
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Falcons -3 vs. Seahawks

• Matchup: Seattle Seahawks at Atlanta Falcons
• Projected Winner & Margin: Falcons by 13.5 points (Bet on this game at BetMGM)
• Spread: Falcons -3
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Eagles -3 vs. Giants

• Matchup: Philadelphia Eagles at New York Giants
• Projected Winner & Margin: Eagles by 6.6 points (Bet on this game at BetMGM)
• Spread: Eagles -3
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers -3 vs. Cardinals

• Matchup: Los Angeles Chargers at Arizona Cardinals
• Projected Winner & Margin: Chargers by 3.6 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 9 p.m. ET
• Date: Oct. 21
• TV Channel: ESPN+
• Live Stream:

Pick: Colts -3.5 vs. Dolphins

• Matchup: Miami Dolphins at Indianapolis Colts
• Projected Winner & Margin: Colts by 19.6 points (Bet on this game at BetMGM)
• Spread: Colts -3.5
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers +3.5 vs. Ravens

• Matchup: Baltimore Ravens at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 11.1 points (Bet on this game at BetMGM)
• Spread: Ravens -3.5
• Time: 8:15 p.m. ET
• Date: Oct. 21
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Patriots +5.5 vs. Jaguars

• Matchup: New England Patriots vs. Jacksonville Jaguars
• Projected Winner & Margin: Jaguars by 0.5 points (Bet on this game at BetMGM)
• Spread: Jaguars -5.5
• Time: 9:30 a.m. ET
• Date: Oct. 20
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals -6.5 vs. Browns

• Matchup: Cincinnati Bengals at Cleveland Browns
• Projected Winner & Margin: Bengals by 6.6 points (Bet on this game at BetMGM)
• Spread: Bengals -6.5
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Rams -6.5 vs. Raiders

• Matchup: Las Vegas Raiders at Los Angeles Rams
• Projected Winner & Margin: Rams by 9.7 points (Bet on this game at BetMGM)
• Spread: Rams -6.5
• Time: 4:05 p.m. ET
• Date: Oct. 20
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Commanders -7.5 vs. Panthers

• Matchup: Carolina Panthers at Washington Commanders
• Projected Winner & Margin: Commanders by 24.7 points (Bet on this game at BetMGM)
• Spread: Commanders -7.5
• Time: 4:05 p.m. ET
• Date: Oct. 20
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills -9 vs. Titans

• Matchup: Tennessee Titans at Buffalo Bills
• Projected Winner & Margin: Bills by 12.5 points (Bet on this game at BetMGM)
• Spread: Bills -9
• Time: 1 p.m. ET
• Date: Oct. 20
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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