There are 14 games on the NFL’s Week 6 card, with the Titans (+1) among the best bets against the spread, according to our projections. For more suggestions, including parlay opportunities, keep reading.

NFL Picks Against the Spread – Week 6

Jump to Matchup:

Pick: Titans +1 vs. Colts

• Matchup: Indianapolis Colts at Tennessee Titans
• Projected Winner & Margin: Colts by 0.6 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -2.5 vs. Jaguars

• Matchup: Jacksonville Jaguars vs. Chicago Bears
• Projected Winner & Margin: Bears by 13.5 points (Bet on this game at BetMGM)
• Spread: Bears -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 13
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Jets +2.5 vs. Bills

• Matchup: Buffalo Bills at New York Jets
• Projected Winner & Margin: Jets by 3.2 points (Bet on this game at BetMGM)
• Spread: Bills -2.5
• Time: 8:15 p.m. ET
• Date: Oct. 14
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Broncos +3 vs. Chargers

• Matchup: Los Angeles Chargers at Denver Broncos
• Projected Winner & Margin: Broncos by 6.4 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -3 vs. Raiders

• Matchup: Pittsburgh Steelers at Las Vegas Raiders
• Projected Winner & Margin: Steelers by 8.7 points (Bet on this game at BetMGM)
• Spread: Steelers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys +3 vs. Lions

• Matchup: Detroit Lions at Dallas Cowboys
• Projected Winner & Margin: Cowboys by 3.1 points (Bet on this game at BetMGM)
• Spread: Lions -3
• Time: 4:25 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks +3.5 vs. 49ers

• Matchup: San Francisco 49ers at Seattle Seahawks
• Projected Winner & Margin: Seahawks by 1.0 points (Bet on this game at BetMGM)
• Spread: 49ers -3.5
• Time: 8:15 p.m. ET
• Date: Oct. 10
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Saints +3.5 vs. Buccaneers

• Matchup: Tampa Bay Buccaneers at New Orleans Saints
• Projected Winner & Margin: Saints by 0.2 points (Bet on this game at BetMGM)
• Spread: Buccaneers -3.5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +3.5 vs. Bengals

• Matchup: Cincinnati Bengals at New York Giants
• Projected Winner & Margin: Giants by 5.7 points (Bet on this game at BetMGM)
• Spread: Bengals -3.5
• Time: 8:20 p.m. ET
• Date: Oct. 13
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -5 vs. Cardinals

• Matchup: Arizona Cardinals at Green Bay Packers
• Projected Winner & Margin: Packers by 9.6 points (Bet on this game at BetMGM)
• Spread: Packers -5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Falcons -6 vs. Panthers

• Matchup: Atlanta Falcons at Carolina Panthers
• Projected Winner & Margin: Falcons by 17.2 points (Bet on this game at BetMGM)
• Spread: Falcons -6
• Time: 4:25 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders +6.5 vs. Ravens

• Matchup: Washington Commanders at Baltimore Ravens
• Projected Winner & Margin: Commanders by 0.4 points (Bet on this game at BetMGM)
• Spread: Ravens -6.5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Texans -7 vs. Patriots

• Matchup: Houston Texans at New England Patriots
• Projected Winner & Margin: Texans by 11.0 points (Bet on this game at BetMGM)
• Spread: Texans -7
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Eagles -8.5 vs. Browns

• Matchup: Cleveland Browns at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 20.0 points (Bet on this game at BetMGM)
• Spread: Eagles -8.5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.