If you’re looking for the best wager to make among the 16 NFL matchups in Week 4, we’re going with the Chargers at +8 in terms of the point spreads. Don’t stop there, though — see below, because we have plenty more tips, which you could use in a parlay.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 4 Spread Bets

Jump to Matchup:

CLE-LV | NO-ATL | TEN-MIA | PIT-IND | PHI-TB

Pick: Raiders -1 vs. Browns

• Matchup: Cleveland Browns at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 6.3 points (Bet on this game at BetMGM)
• Spread: Raiders -1
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints +1.5 vs. Falcons

• Matchup: New Orleans Saints at Atlanta Falcons
• Projected Winner & Margin: Saints by 0.4 points (Bet on this game at BetMGM)
• Spread: Falcons -1.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins +1.5 vs. Titans

• Matchup: Tennessee Titans at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.0 points (Bet on this game at BetMGM)
• Spread: Titans -1.5
• Time: 7:30 PM ET
• Date: Sept. 30
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -2 vs. Colts

• Matchup: Pittsburgh Steelers at Indianapolis Colts
• Projected Winner & Margin: Steelers by 4.5 points (Bet on this game at BetMGM)
• Spread: Steelers -2
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Buccaneers +2.5 vs. Eagles

• Matchup: Philadelphia Eagles at Tampa Bay Buccaneers
• Projected Winner & Margin: Buccaneers by 2.5 points (Bet on this game at BetMGM)
• Spread: Eagles -2.5
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 4 Total Bets

Jump to Matchup:

Over 46.5 – Bills vs. Ravens

• Matchup: Buffalo Bills at Baltimore Ravens
• Projected Total: 51.5 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: Sept. 29
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 39 – Chiefs vs. Chargers

• Matchup: Kansas City Chiefs at Los Angeles Chargers
• Projected Total: 38.0 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 43.5 – Vikings vs. Packers

• Matchup: Minnesota Vikings at Green Bay Packers
• Projected Total: 41.3 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 42.5 – Saints vs. Falcons

• Matchup: New Orleans Saints at Atlanta Falcons
• Projected Total: 42.8 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 40 – Steelers vs. Colts

• Matchup: Pittsburgh Steelers at Indianapolis Colts
• Projected Total: 32.7 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 29
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.