Looking for the best bet among all 49 FBS matchups in Week 10? Our selection, in terms of the point spreads, is Oregon at -3.5 — but scroll down, because we have lots more suggestions, which could lead to parlay possibilities.

Get insights and computer predictions for that matchup and more below.

BetMGM is one of the most trusted Sportsbooks in the nation. Start with as little as $1 and place your bets today.

College Football Computer Picks – Best Spread Bets

Watch college football this season on Fubo and ESPN+.

Pick: Oregon -3.5 vs. Michigan

• Matchup: Oregon Ducks at Michigan Wolverines
• Projected Winner & Margin: Oregon by 18 points
• Time: 3:30 PM ET
• Date: Nov. 2
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Pick: Florida +20.5 vs. Georgia

• Matchup: Florida Gators vs. Georgia Bulldogs
• Projected Winner & Margin: Georgia by 8 points
• Time: 3:30 PM ET
• Date: Nov. 2
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Louisville +8.5 vs. Clemson

• Matchup: Louisville Cardinals at Clemson Tigers
• Projected Winner & Margin: Clemson by 5.1 points
• Time: 7:30 PM ET
• Date: Nov. 2
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ohio State -3.5 vs. Penn State

• Matchup: Ohio State Buckeyes at Penn State Nittany Lions
• Projected Winner & Margin: Ohio State by 3.8 points
• Time: 12:00 PM ET
• Date: Nov. 2
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Use these spread picks at BetMGM today!

College Football Computer Picks – Best Total Bets

Take advantage of our picks and place your bet at BetMGM today!

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.